Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle.

Abstract

Dantrolene inhibits and ryanodine stimulates calcium release from skeletal-muscle sarcoplasmic reticulum (SR), the former by an unknown mechanism, and the latter by activating the ryanodine receptor (RyR), the primary Ca2+-release channel of SR. Dantrolene is used to treat malignant hyperthermia (MH), a genetic predisposition to excessive intracellular Ca2… (More)

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@article{Palnitkar1997PharmacologicalDB, title={Pharmacological distinction between dantrolene and ryanodine binding sites: evidence from normal and malignant hyperthermia-susceptible porcine skeletal muscle.}, author={Samir Palnitkar and Julie Mickelson and Christos Louis and Jerome Parness}, journal={The Biochemical journal}, year={1997}, volume={326 ( Pt 3)}, pages={847-52} }