Pharmacological differentiation between intracellular calcium pump isoforms.

  title={Pharmacological differentiation between intracellular calcium pump isoforms.},
  author={Simone Engelender and Leopoldo de Meis},
  journal={Molecular pharmacology},
  volume={50 5},
We studied the Ca(2+)-ATPase isoforms of sarco/endoplasmic reticulum (SERCA) derived from cerebellum, cardiac muscle, and skeletal muscle. The Mg2+ dependence varied among the three enzyme preparations. The Ca2+ transport in skeletal muscle vesicles, but not in cerebellar or cardiac vesicles, was activated by free Mg2+ concentrations varying from 0.1 to 0.3 mM. Concentrations of Mg2+ of > 1 mM inhibited Ca2+ transport in all three vesicle preparations but with more pronounced effect in… CONTINUE READING

Similar Papers

Loading similar papers…