Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021.

Abstract

BN 52021 antagonized PAF-acether-induced bronchoconstriction (BC) in the guinea-pig and inhibited BC triggered by antigen in passively sensitized animals. The anti-anaphylactic activity was prevented by propranolol and may either result from an additional property of the drug, independent from PAF antagonism or from different PAF-dependent mechanisms with different responsiveness to the various antagonists.

Cite this paper

@article{Vilain1986PharmacologicalCO, title={Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021.}, author={B. Vilain and Vincent Lagente and C. Touvay and S Desquand and Jacques Randon and Jean Lefort and Pierre G. Braquet and Bernardo Boris Vargaftig}, journal={Pharmacological research communications}, year={1986}, volume={18 Suppl}, pages={119-26} }