Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons.

@article{Mahmoud2011PharmacologicalCO,
  title={Pharmacological consequence of the A118G μ opioid receptor polymorphism on morphine- and fentanyl-mediated modulation of Ca²⁺ channels in humanized mouse sensory neurons.},
  author={Saifeldin Ahmed Mahmoud and Annika Thorsell and Wolfgang H. Sommer and Markus Heilig and Joan K Holgate and Selena E Bartlett and Victor Ruiz-Velasco},
  journal={Anesthesiology},
  year={2011},
  volume={115 5},
  pages={1054-62}
}
BACKGROUND The most common functional single nucleotide polymorphism of the human OPRM1 gene, A118G, has been shown to be associated with interindividual differences in opioid analgesic requirements, particularly with morphine, in patients with acute postoperative pain. The purpose of this study was to examine whether this polymorphism would modulate the morphine and fentanyl pharmacological profile of sensory neurons isolated from a humanized mouse model homozygous for either the 118A or 118G… CONTINUE READING

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