Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity.

@article{Shidahara2016PharmacologicalCO,
  title={Pharmacological comparison of a nonhuman primate and a rat model of oxaliplatin-induced neuropathic cold hypersensitivity.},
  author={Yuka Shidahara and Shinya Ogawa and Mari Nakamura and Shingo Nemoto and Yūji Awaga and Miyuki Takashima and Aldric Hama and Akihisa Matsuda and Hiroyuki Takamatsu},
  journal={Pharmacology research & perspectives},
  year={2016},
  volume={4 1},
  pages={
          e00216
        }
}
Oxaliplatin is a first-line treatment for colorectal cancer. However, shortly following treatment, cold-evoked hypersensitivity appears in the extremities and over time, the pain is such that oxaliplatin dosing may need to be markedly reduced or even terminated. There is currently a lack of efficacious treatments for oxaliplatin-induced peripheral neuropathy, which is due in part to the difficulty in translating findings obtained from preclinical rodent models of chemotherapy-induced peripheral… CONTINUE READING
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