Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226.

@article{Doods1995PharmacologicalCO,
  title={Pharmacological characterization of the selective nonpeptide neuropeptide Y Y1 receptor antagonist BIBP 3226.},
  author={Henri N. Doods and Wolfgang Wienen and Michael Entzeroth and K. Rudolf and Werner Eberlein and Wolfhard Engel and Heike A. Wieland},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1995},
  volume={275 1},
  pages={136-42}
}
The present study was undertaken to investigate the in vitro and in vivo pharmacological profile of the novel, nonpeptide neuropeptide Y (NPY) Y1-selective antagonist, BIBP 3226 [(R)-N2-(diphenylacetyl)-N-[(4-hydroxyphenyl)methyl]-D-arginine-am ide], and a recently described peptidic structure [Ile-Glu-Pro-Orn-Tyr-Arg-Leu-Arg-Tyr-NH2, cyclic (2,4'), (2',4)-diamide]. BIBP 3226 antagonized the NPY Y1 receptor-mediated decrease in the twitch response in the rabbit vas deferens preparation with a… CONTINUE READING

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