Pharmacological characterization of the serotonin-sensitive potassium channel of Aplysia sensory neurons

@article{Shuster1987PharmacologicalCO,
  title={Pharmacological characterization of the serotonin-sensitive potassium channel of Aplysia sensory neurons},
  author={Michael J Shuster and Steven A. Siegelbaum},
  journal={The Journal of General Physiology},
  year={1987},
  volume={90},
  pages={587 - 608}
}
The effects of a variety of K+ channel blockers on current flow through single serotonin-sensitive K+ channels (the S channels) of Aplysia sensory neurons were studied using the patch-clamp technique. Tetraethylammonium (TEA), 4-aminopyridine (4-AP), and Co2+ and Ba2+ were first applied to the external membrane surface using cell-free outside-out patches. At concentrations up to 10 mM, these agents had little or no effect on single S-channel currents. At higher concentrations, external TEA… CONTINUE READING