Pharmacological characterization of the effects of verapamil and nifedipine on isolated guinea-pig lung parenchymal strip.

Abstract

Verapamil and nifedipine elicited dose-related relaxations and produced a right downward shift of the concentration-response curves to CaCl2, KCl, acetylcholine and histamine in the isolated guinea-pig lung parenchymal strip. These Ca-entry blockers had greater inhibitory effects on contractions evoked by CaCl2 and KCl than against those elicited by… (More)

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