Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists.

@article{Bagdy1992PharmacologicalCO,
  title={Pharmacological characterization of serotonin receptor subtypes involved in vasopressin and plasma renin activity responses to serotonin agonists.},
  author={Gy{\"o}rgy Bagdy and Alan F. Sved and Dennis L. Murphy and K. Szemer{\'e}di},
  journal={European journal of pharmacology},
  year={1992},
  volume={210 3},
  pages={285-9}
}
Serotonergic drugs with 5-HT2 receptor agonist properties have been suggested to increase plasma vasopressin concentration, blood pressure (BP) and plasma renin activity (PRA). To study whether these actions are mediated by the same or different receptors, we used three potent 5-HT agonists with different structures and receptor binding profiles. All drugs were administered i.v. to conscious, unrestrained rats. The selective agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI), which… CONTINUE READING

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