Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus.

  title={Pharmacological characterization of serotonergic receptor activity in the hypoglossal nucleus.},
  author={Polina Fenik and Sigrid Carlen Veasey},
  journal={American journal of respiratory and critical care medicine},
  volume={167 4},
State-dependent reductions in serotonin delivery to upper airway dilator motoneuron activity may contribute to sleep apnea. The functional significance of serotonin receptor subtypes implicated in excitation of dilator motor neurons was evaluated in anesthetized, paralyzed, mechanically ventilated adult rats (n = 108). The effects of antagonists selective for serotonin receptor subtypes 2A, 2C, or 7 on intrinsic hypoglossal activity and on serotonin agonist (serotonin, 5-carboxamidotryptamine… CONTINUE READING
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