Pharmacological characterization of orphanin FQ/nociceptin and its fragments.

@article{Rossi1997PharmacologicalCO,
  title={Pharmacological characterization of orphanin FQ/nociceptin and its fragments.},
  author={Grace C. Rossi and Liza Leventhal and Elizabeth A. Bolan and Gavril W Pasternak},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1997},
  volume={282 2},
  pages={858-65}
}
The cloning of a fourth member of the opioid receptor family has led to the discovery of a new neuropeptide termed orphanin FQ or nociceptin (OFQ/N). Studies in CD-1 mice confirm the ability of OFQ/N to rapidly induce hyperalgesia within 15 min which is insensitive to opioid antagonists. This is followed in the next 30 min by loss of hyperalgesia and the appearance of analgesia in the tailflick assay which is readily reversed by opioid antagonists. However, the very poor affinity of OFQ/N for… CONTINUE READING

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[Nociceptin/orphanin FQ (N/OFQ)--the opioid, antiopioid or neuromodulator?].

Postepy higieny i medycyny doswiadczalnej • 2004
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