Pharmacological characterization of neural mechanisms regulating mucosal ion transport in mouse jejunum.

  title={Pharmacological characterization of neural mechanisms regulating mucosal ion transport in mouse jejunum.},
  author={Russell J Sheldon and M E Malarchik and Deborah A. Fox and Thomas F. Burks and F rank Porreca},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={249 2},
Neural regulation of electrolyte transport in mouse jejunum was investigated in vitro using: 1) a full-thickness intestinal segment (intact preparation) and 2) a mucosal preparation, consisting of only mucosa, basement membrane and muscularis mucosa. In Ussing chambers, intact tissues exhibited high- and low-frequency oscillations of basal transmural potential difference (PD) and short-circuit current (Isc), whereas mucosal tissues exhibited only low-frequency oscillation of these parameters… CONTINUE READING
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