Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus.

@article{PellegriniGiampietro1994PharmacologicalCO,
  title={Pharmacological characterization of metabotropic glutamate receptors coupled to phospholipase D in the rat hippocampus.},
  author={Domenico E. Pellegrini-Giampietro and S A Torregrossa and Flavio Moroni},
  journal={British journal of pharmacology},
  year={1994},
  volume={118 4},
  pages={
          1035-43
        }
}
1. Phospholipase D (PLD) is the key enzyme in a signal transduction pathway leading to the formation of the second messengers phosphatidic acid and diacylglycerol. In order to define the pharmacological profile of PLD-coupled metabotropic glutamate receptors (mGluRs), PLD activity was measured in slices of adult rat brain in the presence of mGluR agonists or antagonists. Activation of the phospholipase C (PLC) pathway by the same agents was also examined. 2. The mGluR-selective agonist (1S,3R… CONTINUE READING
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