Pharmacological characterization of intraplantar Complete Freund's Adjuvant-induced burrowing deficits.


BACKGROUND It has recently been suggested that non-reflex behavioral readouts, such as burrowing, may be used to evaluate the efficacy of analgesics in rodent models of pain. OBJECTIVE To confirm whether intraplantar Complete Freund's Adjuvant (CFA)-induced pain reliably results in burrowing deficits which can be ameliorated by clinically efficacious… (More)
DOI: 10.1016/j.bbr.2015.12.019