Pharmacological characterization of human incretin receptor missense variants.

@article{Fortin2010PharmacologicalCO,
  title={Pharmacological characterization of human incretin receptor missense variants.},
  author={J. Fortin and Jonathan C Schroeder and Yuantee Zhu and Martin Beinborn and Alan S. Kopin},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2010},
  volume={332 1},
  pages={
          274-80
        }
}
Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) are gut-derived incretin hormones that regulate blood glucose levels. In addition to their widely accepted insulinotropic role, there is evidence that GLP-1 modulates feeding behavior and GIP regulates lipid metabolism, thereby promoting postprandial fat deposition. In this study, we investigated whether naturally occurring polymorphisms in the GLP-1 receptor (GLP-1R) and the GIP receptor (GIP-R) affect the… CONTINUE READING

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