Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices.

@article{Chattipakorn2002PharmacologicalCO,
  title={Pharmacological characterization of glycine-gated chloride currents recorded in rat hippocampal slices.},
  author={Siriporn Chattipakorn Chattipakorn and Lori L. McMahon},
  journal={Journal of neurophysiology},
  year={2002},
  volume={87 3},
  pages={1515-25}
}
An inhibitory role for strychnine-sensitive glycine-gated chloride channels (GlyRs) in mature hippocampus has been overlooked, largely due to the misconception that GlyR expression ceases early during development and to few functional studies demonstrating their presence. As a result, little is known regarding the physiological and pharmacological properties of native GlyRs expressed by hippocampal neurons. In this study, we used pharmacological tools and whole cell patch-clamp recordings of… CONTINUE READING
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