Pharmacological characterization of glutamate binding sites in cultured cerebellar granule cells and cortical astrocytes

@article{Holopainen2004PharmacologicalCO,
  title={Pharmacological characterization of glutamate binding sites in cultured cerebellar granule cells and cortical astrocytes},
  author={I. Holopainen and P. Saransaari and S. Oja},
  journal={Neurochemical Research},
  year={2004},
  volume={19},
  pages={111-115}
}
Membranes prepared from cerebellar granule cells and cortical astrocytes exhibited specific, saturable binding ofl-[3H]glutamate. The apparent binding constant Kd was 135 nM and 393 nM and the maximal binding capacity Bmax 42 and 34 μmol/kg in granule cells and astrocytes, respectively. In granule cells the binding was strongly inhibited by the glutamate receptor agonists kainate, quisqualate, N-methyl-d-aspartate (NMDA),l-homocysteate and ibotenate, and the antagonistdl-5… Expand
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