Pharmacological characterization of dopamine transport in cultured rat astrocytes.

  title={Pharmacological characterization of dopamine transport in cultured rat astrocytes.},
  author={Masato Inazu and Nami Kubota and Hiroshi Takeda and Jun Zhang and Yuji Kiuchi and Katsuji Oguchi and Teruhiko Matsumiya},
  journal={Life sciences},
  volume={64 24},
The effects of GBR-12909 (selective DA uptake inhibitor), zimelidine (selective 5-HT uptake inhibitor) and nisoxetine (selective NE uptake inhibitor) on the uptake of 30 nM [3H]DA into cultured rat astrocytes were examined. [3H]DA uptake was inhibited by approximately 50% by GBR-12909 or zimelidine in a concentration-dependent manner (100 nM to approximately 10 microM). Furthermore, the inhibition curves of GBR-12909 were biphasic, and uptake was completely inhibited by a high concentration of… CONTINUE READING

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