Pharmacological characterization of central and peripheral type I and type II adrenal steroid receptors in the prairie vole, a glucocorticoid-resistant rodent.

@article{Hastings1999PharmacologicalCO,
  title={Pharmacological characterization of central and peripheral type I and type II adrenal steroid receptors in the prairie vole, a glucocorticoid-resistant rodent.},
  author={Nicholas B. Hastings and Miles Orchinik and Maryse V Aubourg and Bruce S. McEwen},
  journal={Endocrinology},
  year={1999},
  volume={140 10},
  pages={4459-69}
}
The prairie vole (Microtus ochrogaster) has recently been shown to be glucocorticoid resistant; that is, the prairie vole adrenal axis is refractory to dexamethasone challenge, and highly elevated basal corticosterone titers occur without apparent pathophysiology. This study investigates the physiological correlates of glucocorticoid resistance in the prairie vole. We provide a detailed pharmacological characterization of intracellular type I and type II adrenal steroid receptors in peripheral… CONTINUE READING

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