Pharmacological characterization of cellular mechanisms of the renal vasodilatory effect of nicotine in rats.

@article{ElMas2008PharmacologicalCO,
  title={Pharmacological characterization of cellular mechanisms of the renal vasodilatory effect of nicotine in rats.},
  author={Mahmoud M El-Mas and Sahar M. El-gowilly and Eman Y. Gohar and Abdel-Rheem M Ghazal},
  journal={European journal of pharmacology},
  year={2008},
  volume={588 2-3},
  pages={294-300}
}
Nicotine causes vasodilation in the renal vasculature through as yet unidentified mechanism. This study investigated the role of endothelial and non-endothelial factors in the vasodilatory action of nicotine in the rat isolated kidney. Nicotine vasodilation in phenylephrine-preconstricted perfused kidneys was evaluated in the absence and presence of drugs that interfere with nitric oxide synthase (NOS), K+ channels, cholinergic or adrenergic activity. Nicotine infusion (5 x 10(-5), 1 x 10(-4… CONTINUE READING

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