Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques.

@article{Marston1998PharmacologicalCO,
  title={Pharmacological characterization of a simple behavioral response mediated selectively by central adenosine A1 receptors, using in vivo and in vitro techniques.},
  author={Hugh M. Marston and Keith Finlayson and Takuya Maemoto and Henry J. Olverman and Atsushi Akahane and J. Brian Sharkey and Steven P. Butcher},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1998},
  volume={285 3},
  pages={1023-30}
}
The behavioral profile of a range of adenosine receptor ligands was examined in rats using a locomotor activity model. Adenosine receptor agonists, including the selective A1 receptor agonist, N6-cyclopentyladenosine (CPA) and the A2A agonist, 2-[(2-aminoethylamino)carbonylethyl-phenylethylamino]- 5'-ethylcarboxa midoadenosine (APEC), reduced spontaneous motor activity in a dose-dependent manner. CPA-induced locomotor depression was attenuated by adenosine A1 receptor selective antagonists… CONTINUE READING

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