Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes

  title={Pharmacological characterization of a nicotinic autoreceptor in rat hippocampal synaptosomes},
  author={G. I. Wilkie and P. G. Hutson and James P. Sullivan and Dr. S. Wonnacott},
  journal={Neurochemical Research},
The modulation of [3H]ACh release by nicotinic compounds was studied in superfused rat hippocampal synaptosomes loaded with [3H]choline. (−)-Nicotine (0.1–10 μM) evoked a dose-dependent increase in [3H]ACh release; higher concentrations were less effective. Nicotine-evoked release was Ca2+-dependent, and blocked by the nicotinic antagonists dihydro-β-erythroidine, mecamylamine, and pempidine. The α7-selective antagonist methyllycaconitine did not inhibit nicotine-evoked release when tested at 1… CONTINUE READING


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