Corpus ID: 347428

Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist.

@article{Ghai1987PharmacologicalCO,
  title={Pharmacological characterization of CGS 15943A: a novel nonxanthine adenosine antagonist.},
  author={Geetha Ghai and Joseph Francis and M. Williams and Ronald Dotson and Maria Hopkins and D T Cot{\'e} and F. R. Goodman and Mark B. Zimmerman},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1987},
  volume={242 3},
  pages={
          784-90
        }
}
CGS 15943A is a potent adenosine receptor antagonist with a novel nonxanthine heterocyclic ring structure. In vitro, CGS 15943A competitively inhibited the 2-chloroadenosine-induced A2 receptor-mediated relaxation of dog coronary artery strips contracted with KCl (25 mM). Similarly, CGS 15943A blocked 2-chloroadenosine- and N-ethylcarboxamideadenosine-induced A2 receptor-mediated relaxation of histamine-contracted guinea pig tracheal strips. Schild analysis of these results yielded pA2 values… Expand
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