Pharmacological characterization of BR-A-657, a highly potent nonpeptide angiotensin II receptor antagonist.

Abstract

The pharmacological profile of BR-A-657, 2-n-butyl-5-dimethylamino-thiocarbonyl-methyl-6-methyl-3-{[2-(1H-tetrazole-5-yl)biphenyl-4-yl]methyl}-pyrimidin-4(3H)-one, a new nonpeptide AT1-selective angiotensin receptor antagonist, has been investigated in a variety of in vitro and in vivo experimental models. In the present study, BR-A-657 displaced [(125)I… (More)

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Cite this paper

@article{Chi2013PharmacologicalCO, title={Pharmacological characterization of BR-A-657, a highly potent nonpeptide angiotensin II receptor antagonist.}, author={Yong Ha Chi and Joo Han Lee and Je Hak Kim and Hyun Kwang Tan and Sang Lin Kim and Jae Yeol Lee and H Rim and Soo Heui Paik and Kyung-Tae Lee}, journal={Biological & pharmaceutical bulletin}, year={2013}, volume={36 7}, pages={1208-15} }