Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes.

@article{Grahames1999PharmacologicalCO,
  title={Pharmacological characterization of ATP- and LPS-induced IL-1beta release in human monocytes.},
  author={Caroline B. A. Grahames and Anton D. Michel and Iain Chessell and Patrick P. A. Humphrey},
  journal={British journal of pharmacology},
  year={1999},
  volume={127 8},
  pages={1915-21}
}
1. We have utilized the human monocytic cell line, THP-1, and freshly isolated adherent human monocytes with the compounds pyridoxalphosphate-6-azophenyl-2',4'-disuphonic acid (PPADS), oxidized ATP, and 1-(N, O-bis[5-isoquinolinesufonyll]-N-methyl-L-tyrosyl)-4-phenylpiper azi ne (KN-62) to pharmacologically characterize the P2 receptor involved in ATP-induced release of interleukin 1beta (IL-1beta). We have also investigated the involvement of P2 receptors in lipopolysaccharide (LPS)-induced IL… CONTINUE READING

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