Pharmacological characterization of A2-adenosine receptors in guinea-pig ventricular cardiomyocytes.

  title={Pharmacological characterization of A2-adenosine receptors in guinea-pig ventricular cardiomyocytes.},
  author={Birgitt Stein and W. Schmitz and Hasso Scholz and C Seeland},
  journal={Journal of molecular and cellular cardiology},
  volume={26 3},
The aim of the present study was to elucidate the question of whether cardiomyocytes possess stimulatory adenylyl cyclase-coupled A2-adenosine receptors and whether these receptors modify contractility. In isolated electrically driven ventricular cardiomyocytes from guinea-pig hearts the effects of the A2-adenosine receptor agonist 2-[(p-2-carboxyethyl)-phenethylamino]-5'-N-ethylcarboxamide-adenos ine (CGS 21680C) alone and in the presence of isoprenaline on cAMP content and contractile… CONTINUE READING


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