Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate.

@article{Juvin2007PharmacologicalCA,
  title={Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate.},
  author={V{\'e}ronique Juvin and Aubin Penna and Jean Chemin and Y L Lin and F Rassendren},
  journal={Molecular pharmacology},
  year={2007},
  volume={72 5},
  pages={1258-68}
}
Despite its expression in different cell types, transient receptor potential V2 (TRPV2) is still the most cryptic members of the TRPV channel family. 2-Aminoethoxydiphenyl borate (2APB) has been shown to be a common activator of TRPV1, TRPV2, and TRPV3, but 2APB-triggered TRPV2 activation remains to be thoroughly characterized. In this study, we have developed an assay based on cell lines stably expressing mouse TRPV2 channels and intracellular calcium measurements to perform a pharmacological… CONTINUE READING
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