Pharmacological characterisation of the thermogenic effect of bupropion.

@article{Liu2004PharmacologicalCO,
  title={Pharmacological characterisation of the thermogenic effect of bupropion.},
  author={Yue Liang Liu and Ian P Connoley and David J Heal and Michael J. Stock},
  journal={European journal of pharmacology},
  year={2004},
  volume={498 1-3},
  pages={
          219-25
        }
}
The pharmacological mechanism of bupropion's thermogenic effect has been investigated in female Wistar rats by measuring oxygen consumption at thermoneutrality (29 degrees C). Bupropion (30 mg/kg) rapidly increased oxygen consumption (VO2) with a maximum effect at 30 min, and VO2 remained elevated throughout the 4-h experimental period. The nonselective 5-hydroxytryptamine (5-HT or serotonin) receptor antagonist, metergoline (1 mg/kg), and the alpha1-adrenoceptor antagonist, prazosin (1 mg/kg… CONTINUE READING
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