Pharmacological characterisation of the plant sesquiterpenes polygodial and drimanial as vanilloid receptor agonists.

@article{Andr2006PharmacologicalCO,
  title={Pharmacological characterisation of the plant sesquiterpenes polygodial and drimanial as vanilloid receptor agonists.},
  author={Eunice Andr{\'e} and Barbara Campi and Marcello Trevisani and Juliano Ferreira and Angela Malheiros and Rosendo Augusto Yunes and Jo{\~a}o Batista Calixto and Pierangelo Geppetti},
  journal={Biochemical pharmacology},
  year={2006},
  volume={71 8},
  pages={1248-54}
}
This study was designed to assess the participation of transient receptor potential vanilloid 1 (TRPV1) in the biological effects induced by the plant-derived sesquiterpenes polygodial and drimanial. In rat isolated urinary bladder, polygodial and drimanial produced a tachykinin-mediated contraction that was inhibited by combination of NK(1) and NK(2… CONTINUE READING