Pharmacological characterisation of the mechanisms underlying the relaxant effect of adrenomedullin in the rat carotid artery.

@article{Passaglia2014PharmacologicalCO,
  title={Pharmacological characterisation of the mechanisms underlying the relaxant effect of adrenomedullin in the rat carotid artery.},
  author={Patr{\'i}cia Passaglia and Nat{\'a}lia Almeida Gonzaga and Daniela Pretti da Cunha Tirapelli and Lu{\'i}s Fernando Tirapelli and Carlos Renato Tirapelli},
  journal={The Journal of pharmacy and pharmacology},
  year={2014},
  volume={66 12},
  pages={1734-46}
}
OBJECTIVES We investigated the mechanisms underlying the relaxant effect of adrenomedullin (AM) in the rat carotid artery and verified the expression of AM system components in this tissue. METHODS The carotid artery was isolated from male Wistar rats and immunohistochemical, Western immunoblotting, real-time polymerase chain reaction and functional assays were conducted. KEY FINDINGS Protein and mRNA expression of AM, calcitonin receptor-like receptor (CRLR) and receptor activity-modifying… CONTINUE READING
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