Pharmacological characterisation of the enantiomers of BM-5, a muscarinic partial agonist with opposed enantioselectivity between affinity and efficacy.

@article{Sundquist2000PharmacologicalCO,
  title={Pharmacological characterisation of the enantiomers of BM-5, a muscarinic partial agonist with opposed enantioselectivity between affinity and efficacy.},
  author={Staffan Sundquist and A R Modiri and Bj{\"o}rn M. Nilsson and Uli Hacksell and Per G{\"o}ran Gillberg and Lisbeth Nilvebrant},
  journal={Pharmacology \& toxicology},
  year={2000},
  volume={86 1},
  pages={
          44-50
        }
}
The interaction of (R) and (S) enantiomers of the chiral oxotremorine analogue BM-5 with muscarinic acetylcholine receptors was studied in vitro using radioligand binding and isolated tissue preparations. The in vivo effects of (R)-BM-5 were also studied in anaesthetised cat. No receptor or tissue selectivity was found for either enantiomer in radioligand binding studies in cells expressing human muscarinic receptors (M1-M5) or in guinea pig tissues. The affinity of (R)-BM-5 was about 40 times… 
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