Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors

@article{Knight2004PharmacologicalCO,
  title={Pharmacological characterisation of the agonist radioligand binding site of 5-HT2A, 5-HT2B and 5-HT2C receptors},
  author={A. R. Knight and A. Misra and K. Quirk and K. Benwell and D. Revell and G. Kennett and M. Bickerdike},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2004},
  volume={370},
  pages={114-123}
}
In the present study we compared the affinity of various drugs for the high affinity “agonist-preferring” binding site of human recombinant 5-HT2A, 5-HT2B and 5-HT2C receptors stably expressed in monoclonal mammalian cell lines. To ensure that the “agonist-preferring” conformation of the receptor was preferentially labelled in competition binding experiments, saturation analysis was conducted using antagonist and agonist radiolabels at each receptor. Antagonist radiolabels ([3H]-ketanserin for… Expand
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