Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors

@inproceedings{Bretin2017PharmacologicalCO,
  title={Pharmacological characterisation of S 47445, a novel positive allosteric modulator of AMPA receptors},
  author={Sylvie Bretin and Caroline Louis and Laure Seguin and St{\'e}phanie Wagner and Jaron Michael Thomas and Sylvie Challal and Nathalie Rogez and Karine Albinet and Fabrice Iop and Nad{\`e}ge Villain and Sandrine Bertrand and Ali Krazem and Daniel B{\'e}rachoch{\'e}a and St{\'e}phanie Billiald and Charles Tordjman and Alexis A. Cordi and Daniel Bertrand and Pierre Lestage and Laurence Danober},
  booktitle={PloS one},
  year={2017}
}
S 47445 is a novel positive allosteric modulator of alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors (AMPA-PAM). S 47445 enhanced glutamate's action at AMPA receptors on human and rat receptors and was inactive at NMDA and kainate receptors. Potentiation did not differ among the different AMPA receptors subtypes (GluA1/2/4 flip and flop variants) (EC50 between 2.5-5.4 μM), except a higher EC50 value for GluA4 flop (0.7 μM) and a greater amount of potentiation on GluA1… CONTINUE READING

References

Publications referenced by this paper.
SHOWING 1-10 OF 68 REFERENCES

Similar Papers

Loading similar papers…