Pharmacological chaperoning of nAChRs: a therapeutic target for Parkinson's disease.

Abstract

Chronic exposure to nicotine results in an upregulation of neuronal nicotinic acetylcholine receptors (nAChRs) at the cellular plasma membrane. nAChR upregulation occurs via nicotine-mediated pharmacological receptor chaperoning and is thought to contribute to the addictive properties of tobacco as well as relapse following smoking cessation. At the… (More)
DOI: 10.1016/j.phrs.2014.02.005

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