Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats.


The Nociceptin/OrphaninFQ (NOP) system is believed to be involved in drug abuse and addiction. We have recently demonstrated that activation of the NOP receptor, by systemic administration of the NOP receptor agonist Ro65-6570, attenuated the rewarding effect of various opioids in conditioned place preference (CPP) in rats and this attenuating effect was… (More)
DOI: 10.1016/j.drugalcdep.2010.10.004


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