Pharmacological blockade of small conductance Ca2+-activated K+ channels by ICA reduces arrhythmic load in rats with acute myocardial infarction

@article{Hundahl2017PharmacologicalBO,
  title={Pharmacological blockade of small conductance Ca2+-activated K+ channels by ICA reduces arrhythmic load in rats with acute myocardial infarction},
  author={Laura A. Hundahl and Stefan M Sattler and Lasse Skibsbye and Jonas G Diness and Jacob Tfelt-Hansen and Thomas Jespersen},
  journal={Pfl{\"u}gers Archiv - European Journal of Physiology},
  year={2017},
  volume={469},
  pages={739-750}
}
Acute myocardial infarction (AMI) with development of ventricular fibrillation (VF) is a common cause of sudden cardiac death (SCD). At present, no pharmacological treatment has successfully been able to prevent VF in the acute stage of AMI. This study investigates the antiarrhythmic effect of inhibiting small conductance Ca2+-activated K+ (SK) channels using the pore blocker N-(pyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (ICA) in AMI rats. Acute coronary ligation was performed in 26… CONTINUE READING

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