Pharmacological benefits of agomelatine and vanillin in experimental model of Huntington's disease.

@article{Gupta2014PharmacologicalBO,
  title={Pharmacological benefits of agomelatine and vanillin in experimental model of Huntington's disease.},
  author={Surbhi Gupta and Brij Mohan Sharma},
  journal={Pharmacology, biochemistry, and behavior},
  year={2014},
  volume={122},
  pages={122-35}
}
Huntington's disease (HD), a devastating neurodegenerative disorder, is characterized by progressive motor dysfunction, emotional disturbances, dementia, weight loss, depression. Melatonin receptors are widely expressed in the central nervous system. Vanilloids are also valuable as pharmacological tools for investigating neurobiology. This study investigates the utility of agomelatine, a dual agonist of MT₁ and MT₂ melatonin receptor as well as vanillin, a selective agonist of TRPV₁ (vanilloid… CONTINUE READING

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