Pharmacological basis for the medicinal use of Zanthoxylum armatum in gut, airways and cardiovascular disorders

@article{Gilani2010PharmacologicalBF,
  title={Pharmacological basis for the medicinal use of Zanthoxylum armatum in gut, airways and cardiovascular disorders},
  author={S. N. Gilani and Arif-Ullah Khan and A. Gilani},
  journal={Phytotherapy Research},
  year={2010},
  volume={24}
}
This study describes the gut, airways and cardiovascular modulatory activities of Zanthoxylum armatum DC. (Rutaceae) to rationalize some of its medicinal uses. The crude extract of Zanthoxylum armatum (Za.Cr) caused concentration‐dependent relaxation of spontaneous and high K+ (80 mM)‐induced contractions in isolated rabbit jejunum, being more effective against K+ and suggestive of Ca++ antagonist effect, which was confirmed when pretreatment of the tissues with Za.Cr shifted Ca++ concentration… Expand

Paper Mentions

Interventional Clinical Trial
Zanthozylum armatum (Z. armatum)-otherwise known as Nepalese pepper, or timut-is an perennial shrub found in India and across Southeast Asia. Preparations of the bark, fruit and seeds… Expand
ConditionsCognitive Change
InterventionDietary Supplement
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References

SHOWING 1-10 OF 81 REFERENCES
Pharmacological basis for the use of Borago officinalis in gastrointestinal, respiratory and cardiovascular disorders.
TLDR
The results suggest that the spasmolytic effects of Bo.Cr are mediated possibly through Ca++ antagonist mechanism, which might explain the traditional use of Borago officinalis in hyperactive gastrointestinal, respiratory and cardiovascular disorders. Expand
Pharmacological Basis for the Medicinal Use of Ginger in Gastrointestinal Disorders
TLDR
Data indicate that Zo.Cr contains a cholinergic, spasmogenic component evident in stomach fundus preparations which provides a sound mechanistic insight for the prokinetic action of ginger. Expand
Pharmacological basis for the use of turmeric in gastrointestinal and respiratory disorders.
TLDR
The data suggest that the inhibitory effects of Cl.Cr are mediated primarily through calcium channel blockade, though additional mechanism cannot be ruled out and this study forms the basis for the traditional use of turmeric in hyperactive states of the gut and airways. Expand
Species differences in the prokinetic effects of ginger
TLDR
The study showed that the aqueous extract of ginger exhibits species-specific spasmogenicity in gut tissues of rabbit and rat while through an uncharacterized pathway in guinea-pig ileum, along with a dormant relaxant effect, mediated via the blockade of voltage-dependent Ca2 +  channels. Expand
Ca2+ antagonist and cholinergic activities explain the medicinal use of olive in gut disorders
TLDR
It is indicated that olives contain spasmolytic (Ca 2+ antagonists) and spasmogenic (cholinergic) constituents, which provides a scientific base for its medicinal use in gastrointestinal disorders, such as abdominal colic, diarrhea, and constipation. Expand
Species differences in the gut stimulatory effects of radish seeds
TLDR
The study shows species‐specific spasmogenic effects of radish in rabbit, rat and mouse via muscarinic receptors but through an uncharacterized pathway in guinea‐pig tissues. Expand
Ca++ channel blocking activity of Artemisia scoparia extract
TLDR
Data indicate that Artemisia scoparia cntains Ca++ channel blocker‐like constituent(s) which may explain the hypotensive effect observed in vivo and the traditional use of the plant as a spasmolytic. Expand
Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation
TLDR
BSE prevents diarrhoea and normalizes intestinal motility in pathophysiological states without slowing the rate of transit in control animals, which could explain, at least in part, the clinical efficacy of this Ayurvedic remedy in reducing diarrhoee in patients with inflammatory bowel disease. Expand
Presence of antispasmodic, antidiarrheal, antisecretory, calcium antagonist and acetylcholinesterase inhibitory steroidal alkaloids in Sarcococca saligna.
TLDR
This study provides a sound mechanistic base for some of the traditional uses of the plant in hyperactive gut states, in addition to providing the first evidence for verapamil to possess additional AChE inhibitory activity. Expand
Laxative effect of ispaghula: physical or chemical effect?
TLDR
Results indicate that the stimulatory effect of ispaghula at lower doses is mediated through an ACh‐like mechanism and the effect of high doses was mediated partially through unknown mechanism(s). Expand
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1
2
3
4
5
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