Pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: a quantitative literature review.

@article{Sommer2012PharmacologicalAS,
  title={Pharmacological augmentation strategies for schizophrenia patients with insufficient response to clozapine: a quantitative literature review.},
  author={Iris E. C. Sommer and Marieke J. H. Begemann and Anke Temmerman and Stefan Leucht},
  journal={Schizophrenia bulletin},
  year={2012},
  volume={38 5},
  pages={1003-11}
}
BACKGROUND When schizophrenia patients have insufficient response to clozapine, pharmacological augmentation is often applied. This meta-analysis summarizes available evidence on efficacy of pharmacological augmentation of clozapine treatment in schizophrenia spectrum disorder. METHODS Only double-blind randomized controlled studies were included. Primary outcome measure was total symptom severity, and secondary outcome measures were subscores for positive and negative symptoms. Effect sizes… CONTINUE READING
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