Pharmacological approaches to the treatment of obstructive sleep apnoea.

  title={Pharmacological approaches to the treatment of obstructive sleep apnoea.},
  author={Malcolm Kohler and Konrad E Bloch and John R Stradling},
  journal={Expert opinion on investigational drugs},
  volume={18 5},
BACKGROUND Currently the treatment of choice for symptomatic obstructive sleep apnoea (OSA) is continuous positive airway pressure (CPAP). Some patients with OSA do not tolerate CPAP or have insufficiently severe symptoms to justify its use; for these patients, drug therapy would be a desirable potential therapeutic alternative. OBJECTIVE To summarize the current evidence on the effectiveness of drug therapy in patients with OSA. METHODS A systematic review of randomized controlled trials… CONTINUE READING

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