Pharmacological and toxicological properties of Nigella sativa

@article{Ali2003PharmacologicalAT,
  title={Pharmacological and toxicological properties of Nigella sativa},
  author={B. H. Ali and Gerald Blunden},
  journal={Phytotherapy Research},
  year={2003},
  volume={17}
}
The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as black seed or black cumin, are used in folk (herbal) medicine all over the world for the treatment and prevention of a number of diseases and conditions that include asthma, diarrhoea and dyslipidaemia. This article reviews the main reports of the pharmacological and toxicological properties of N. sativa and its constituents. 
Chemical composition of Nigella sativa Linn: Part 2 Recent advances
TLDR
This review article is an update on the previous article published on Nigella sativa L. in this journal and covers the medicinal properties and chemical syntheses of the alkaloids isolated from the seeds of the herb. Expand
BLACK CUMIN (Nigella sativa) AND ITS ACTIVE COMPONENT OF THYMOQUINONE: EFFECTS ON HEALTH
TLDR
Nigella sativa has the richest historical past of plants in the healthcare field and is believed to have antihypertensive, antihyperlipidemic, antidiabetic, anticancer, antioxidant, antimicrobial, antitumour, antibacterial, anti-inflammtory and immune-system effects through its components. Expand
A review of Nigella sativa plant-based therapy in dermatology.
TLDR
The current literature surrounding the pharmacological effects of N. sativa for the treatment of acne vulgaris, melanoma, vitiligo, atopic dermatitis, plaque psoriasis, and wound healing is reviewed. Expand
Dermatological effects of Nigella sativa
TLDR
In this article, the literature pertaining to dermatological effects of N. sativa is reviewed, the first review in this subject, and it is expected that this review stimulates further studies on the dermatology effects and application of the plant. Expand
Thymoquinone: a promising antidiabetic agent
  • M. AbuKhader
  • Medicine
  • International Journal of Diabetes in Developing Countries
  • 2012
TLDR
The aim of this review is to highlight the potential of thymoquinone as an antidiabetic agent and the latest reported research investigations regarding the molecular mechanism of its hypoglycemic effect. Expand
Dermatological Effects of Nigella sativa and Its Constituent, Thymoquinone
TLDR
N. sativa and TQ may be effective therapeutic agents in various infectious and noninfectious skin conditions including different types of allergy, autoimmunity, skin inflammations and wounds, cancer, and vitiligo. Expand
Medicinal properties of Nigella sativa (Kalonji).
Seeds of Nigella sativa (N. sativa) have been frequently used in folk medicine for several medicinal purposes including to treat cough, asthama, diarrhoea, fever, common cold, headache, rheumaticExpand
The Effects of Nigella Sativa seed and Nigella Sativa Honeybee on Hypercholesterolemic Rats
Plants have been an important source of medicine for thousands of years. The World Health Organization (WHO) estimated that up to 80% of people still rely on herbal remedies for their health careExpand
Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone
TLDR
Some effects of N. sativa, such as its hypoglycemic, hypolipidemic and bronchodilatory effects, have been sufficiently studied and are sufficiently understood to allow for the next phase of clinical trials or drug developments. Expand
Some Biological and Pharmacological Effects of the Black Cumin (Nigella sativa): A Concise Review
This review provides a brief account on the various properties and medicinal usage of the black cumin seed (Nigella sativa). The literature information indicated that seed was extensively used inExpand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 43 REFERENCES
Allergic contact dermatitis from black cumin (Nigella sativa) oil‐containing ointment
TLDR
Black cumin (Nigella sativa), a member of the Ranunculaceae, is found in temperate and cold climates and has a variety of therapeutic effects on digestive disorders, gynecological diseases, and the respiratory system. Expand
Hematological studies on black cumin oil from the seeds of Nigella sativa L.
The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation andExpand
Antioxidant activity of Nigella sativa essential oil
TLDR
A rapid evaluation for antioxidants, using two TLC screening methods, showed that thymoquinone and the components carvacrol, t‐anethole and 4‐terpineol demonstrated respectable radical scavenging property. Expand
The anti-inflammatory, analgesic and antipyretic activity of Nigella sativa.
TLDR
N. sativa crude suspension supports its use in folk medicine both as analgesic and anti-inflammatory agent and calls for further investigations to elucidate its mechanism of action. Expand
Nigellidine — A new indazole alkaloid from the seeds of Nigella sativa
Abstract Nigellidine (1), only the second example of a natural product containing an indazole nucleus, was isolated from Nigella sativa and characterized by spectroscopic and X-ray diffractionExpand
Nigellimine N-oxide-a new isoquinoline alkaloid from the seeds of Nigella sativa
A new isoquinoline alkaloid, nigellimine [1], has been isolatedas a trace constituent from the seeds of Nigella sativa. The structure was assigned on the basis of chemical and spectroscopic studies
Protective effect of cysteine and vitamin E, Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in rats.
TLDR
Le cisplatine est largement utilise en chimiotherapie malgre sa toxicite renale ou d'extrait de Nigella saliva, reduit, chez le rat, les effets secondaires toxiques du cispl atine, nephrotoxicite incluse. Expand
Traditional medicine in health care.
  • M. Sayed
  • Medicine
  • Journal of ethnopharmacology
  • 1980
The state of research on plants used in traditional medicine and its development in Egypt is indicated by the number of scientific institutions devoted to this problem: Universities, the NationalExpand
Antiulcer effects of aqueous extracts of Nigella sativa and Pongamia pinnata in rats
TLDR
The aqueous extract of P. pinnata induced a significant decrease in volume of gastric juice, acid output and peptic activity but no effect on mucin activity in acetylsalicylic acid (ASA)-ulcerated rats, while N. sativa decreased the peptic activiy in ASA- ulcersated rats. Expand
Cytotoxic and immunopotentiating effects of ethanolic extract of Nigella sativa L. seeds.
TLDR
Data indicate that CC-5 possesses a potent cytotoxic effect as well as a potentiating effect on the cellular immune response, and the mechanism whereby it produces this needs to be resolved. Expand
...
1
2
3
4
5
...