Pharmacological and toxicological properties of Nigella sativa

  title={Pharmacological and toxicological properties of Nigella sativa},
  author={B. H. Ali and Gerald Blunden},
  journal={Phytotherapy Research},
The seeds of Nigella sativa Linn. (Ranunculaceae), commonly known as black seed or black cumin, are used in folk (herbal) medicine all over the world for the treatment and prevention of a number of diseases and conditions that include asthma, diarrhoea and dyslipidaemia. This article reviews the main reports of the pharmacological and toxicological properties of N. sativa and its constituents. 

Chemical composition of Nigella sativa Linn: Part 2 Recent advances

This review article is an update on the previous article published on Nigella sativa L. in this journal and covers the medicinal properties and chemical syntheses of the alkaloids isolated from the seeds of the herb.


Nigella sativa has the richest historical past of plants in the healthcare field and is believed to have antihypertensive, antihyperlipidemic, antidiabetic, anticancer, antioxidant, antimicrobial, antitumour, antibacterial, anti-inflammtory and immune-system effects through its components.

Dermatological effects of Nigella sativa

A review of Nigella sativa plant‐based therapy in dermatology

The current literature surrounding the pharmacological effects of N. sativa for the treatment of acne vulgaris, melanoma, vitiligo, atopic dermatitis, plaque psoriasis, and wound healing is reviewed.

Çörek Otunun (Nigella Sativa L.) Aktif Bileşeni Timokinonun İnsan Sağlığı Üzerine Olası Etkileri

on various metabolic pathways. In this review, the pharmacological and toxicological property of thymoquinone, which is the active ingredient of Nigella sativa L. seeds is evaluated. The evidence

Thymoquinone: a promising antidiabetic agent

  • M. AbuKhader
  • Biology
    International Journal of Diabetes in Developing Countries
  • 2012
The aim of this review is to highlight the potential of thymoquinone as an antidiabetic agent and the latest reported research investigations regarding the molecular mechanism of its hypoglycemic effect.

Medicinal properties of Nigella sativa (Kalonji).

Seeds of Nigella sativa (N. sativa) have been frequently used in folk medicine for several medicinal purposes including to treat cough, asthama, diarrhoea, fever, common cold, headache, rheumatic

The Effects of Nigella Sativa seed and Nigella Sativa Honeybee on Hypercholesterolemic Rats

The use of natural products with therapeutic properties is as ancient as human civilization and for a long time, mineral, plant and animal products were the main sources of drugs used for therapeutic purpose.

Review on Clinical Trials of Black Seed (Nigella sativa ) and Its Active Constituent, Thymoquinone

Some effects of N. sativa, such as its hypoglycemic, hypolipidemic and bronchodilatory effects, have been sufficiently studied and are sufficiently understood to allow for the next phase of clinical trials or drug developments.



Allergic contact dermatitis from black cumin (Nigella sativa) oil‐containing ointment

Black cumin (Nigella sativa), a member of the Ranunculaceae, is found in temperate and cold climates and has a variety of therapeutic effects on digestive disorders, gynecological diseases, and the respiratory system.

Hematological studies on black cumin oil from the seeds of Nigella sativa L.

The methanol soluble portion of black cumin oil, which is prepared by compression of seeds of Nigella sativa L., showed inhibitory effects on arachidonic acid (AA)-induced platelet aggregation and

Antioxidant activity of Nigella sativa essential oil

A rapid evaluation for antioxidants, using two TLC screening methods, showed that thymoquinone and the components carvacrol, t‐anethole and 4‐terpineol demonstrated respectable radical scavenging property.

Nigellimine N-oxide-a new isoquinoline alkaloid from the seeds of Nigella sativa

A new isoquinoline alkaloid, nigellimine [1], has been isolatedas a trace constituent from the seeds of Nigella sativa. The structure was assigned on the basis of chemical and spectroscopic studies

Traditional medicine in health care.

  • M. Sayed
  • Biology
    Journal of ethnopharmacology
  • 1980

Antiulcer effects of aqueous extracts of Nigella sativa and Pongamia pinnata in rats

The aqueous extract of P. pinnata induced a significant decrease in volume of gastric juice, acid output and peptic activity but no effect on mucin activity in acetylsalicylic acid (ASA)-ulcerated rats, while N. sativa decreased the peptic activiy in ASA- ulcersated rats.