Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors

@article{Sugrue2000PharmacologicalAO,
  title={Pharmacological and ocular hypotensive properties of topical carbonic anhydrase inhibitors},
  author={Michael F. Sugrue},
  journal={Progress in Retinal and Eye Research},
  year={2000},
  volume={19},
  pages={87-112}
}
There was a time gap of over 40 years between the demonstrated oral effectiveness of acetazolamide in lowering the intraocular pressure (IOP) of glaucoma patients and the introduction of a topical carbonic anhydrase (CA) inhibitor. This is due to the fact that CA-II, the isoenzyme which most likely plays an important role in the production of aqueous humor in humans, must be essentially inhibited by 100% to elicit a pharmacological response. The lack of success with earlier attempts to obtain a… CONTINUE READING
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