Pharmacological and histological characterisation of nicotine-kindled seizures in mice.

@article{Bastlund2005PharmacologicalAH,
  title={Pharmacological and histological characterisation of nicotine-kindled seizures in mice.},
  author={Jesper Frank Bastlund and David J Berry and William P. Watson},
  journal={Neuropharmacology},
  year={2005},
  volume={48 7},
  pages={975-83}
}
The present study reports that it is possible to induce kindling by repeated injections of nicotine. The newly characterised nicotine-kindling model was compared with that of pentylenetetrazole (PTZ) kindling. Mice were kindled by repeated injection of PTZ (37 mg/kg), or nicotine (2.3 mg/kg), and the effect of the anti-epileptic drugs (AED) levetiracetam (LEV), tiagabine (TGB) and phenytoin (PHT) on seizures in kindled and naive mice were investigated. C-Fos immunoreactivity (Fos IR) was used… CONTINUE READING