Pharmacological and histochemical evidence for P2X receptors in human umbilical vessels.

@article{Bo1998PharmacologicalAH,
  title={Pharmacological and histochemical evidence for P2X receptors in human umbilical vessels.},
  author={Xu Bo and Amy Sexton and Zhenghua Xiang and Showan Nori and Geoffrey Burnstock},
  journal={European journal of pharmacology},
  year={1998},
  volume={353 1},
  pages={59-65}
}
The presence of P2X purinoceptors in human umbilical vessels were studied with organ bath recording, radioligand binding assays, autoradiography, and immunohistochemistry. In isolated umbilical arteries and veins from normal term pregnancy, both ATP and alpha,beta-methylene ATP caused concentration-dependent contractions. ATP-induced responses were blocked by desensitisation with alpha,betamethylene ATP. However, both the ATP- and alpha,beta-methylene ATP-induced responses were not antagonised… CONTINUE READING