Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma

  title={Pharmacological and genomic profiling identifies NF-κB–targeted treatment strategies for mantle cell lymphoma},
  author={Rami Rahal and Mareike Frick and Rodrigo Romero and Joshua M. Korn and Robert Kridel and Fong Chun Chan and Barbara Meissner and Hyo-eun C Bhang and Dave Ruddy and Audrey Kauffmann and Ali Farsidjani and Adnan Derti and Daniel P. Rakiec and Tara L. Naylor and Estelle Pfister and Steve G Kovats and Sunkyu Kim and Kerstin Dietze and Bernd Doerken and Christian Steidl and Alexandar Tzankov and Michael Hummel and John E. Monahan and Michael P. Morrissey and Christine Fritsch and William R Sellers and Vesselina G. Cooke and Randy D. Gascoyne and Georg Lenz and Frank Stegmeier},
  journal={Nature Medicine},
Mantle cell lymphoma (MCL) is an aggressive malignancy that is characterized by poor prognosis. Large-scale pharmacological profiling across more than 100 hematological cell line models identified a subset of MCL cell lines that are highly sensitive to the B cell receptor (BCR) signaling inhibitors ibrutinib and sotrastaurin. Sensitive MCL models exhibited chronic activation of the BCR-driven classical nuclear factor-κB (NF-κB) pathway, whereas insensitive cell lines displayed activation of the… CONTINUE READING
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