Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors.

@article{Deneris1991PharmacologicalAF,
  title={Pharmacological and functional diversity of neuronal nicotinic acetylcholine receptors.},
  author={Evan S Deneris and Jeanne Connolly and Scott Warren Rogers and Robert M. Duvoisin},
  journal={Trends in pharmacological sciences},
  year={1991},
  volume={12 1},
  pages={34-40}
}
Recent molecular cloning studies have identified several genes encoding alpha and beta subunits of the nicotinic acetylcholine receptor. These genes have distinct, although overlapping, patterns of expression in the brain and peripheral ganglia. Multiple nicotinic receptors with distinct pharmacological and functional properties can be made in oocytes by pairwise combination of different alpha-type subunits with different beta-type subunits. Both alpha and beta subunits contribute to the… CONTINUE READING