Pharmacological and functional characterisation of the wild-type and site-directed mutants of the human H1 histamine receptor stably expressed in CHO cells.

Abstract

A cDNA clone for the human histamine H1 receptor was isolated from a lung cDNA library and stably expressed in CHO cells. The recombinant receptor protein present in the cell membranes, displayed the functional and binding characteristics of histamine H1 receptors. Mutation of Ser155 to Ala in the fourth transmembrane domain did not significantly change the… (More)

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@article{Moguilevsky1995PharmacologicalAF, title={Pharmacological and functional characterisation of the wild-type and site-directed mutants of the human H1 histamine receptor stably expressed in CHO cells.}, author={Nicole Moguilevsky and F Varsalona and Jean-Loup Guillaume and Mathilde Noyer and Marc Gillard and J Daliers and J. P. H{\'e}nichart and A. W. Bollen}, journal={Journal of receptor and signal transduction research}, year={1995}, volume={15 1-4}, pages={91-102} }