Pharmacological and chemical screening of Byrsonima crassifolia, a medicinal tree from Mexico. Part I.

  title={Pharmacological and chemical screening of Byrsonima crassifolia, a medicinal tree from Mexico. Part I.},
  author={Ezra B{\'e}jar and Marvin H. Malone},
  journal={Journal of ethnopharmacology},
  volume={39 2},
Leaf and bark extracts of Byrsonima crassifolia displayed concentration-dependent, spasmogenic effects on rat fundus in vitro and biphasic effects on rat jejunum and ileum in vitro. Dose-related in vivo effects in intact rats using hippocratic screening were: decrease in motor activity, mild analgesia, back tonus, enophthalmos, reversible palpebral ptosis, ear blanching, Robichaud positive, catalepsy (awake) and strong hypothermia. Rat fundus in vitro was used as the bioassay to carry out an… Expand
Antidepressant effect and pharmacological evaluation of standardized extract of flavonoids from Byrsonima crassifolia.
The present results showed that the methanolic extract standardized on flavonoids content of Byrsonima crassifolia possesses potential antidepressant-like effects in the FST in mice, and could be considered as relatively safe toxicologically with no deaths of mice when orally administered at 2000 mg/kg. Expand
Constituents of Byrsonima Crassifolia and Their Spasmogenic Activity
Biological evaluations showed that five compounds (betulin, betulinic acid, hyperin, quercetin, and ursenaldehyde) exhibited spasmogenic activity on isolated rat fundus, and three isolates showed noncompetitive antagonism to serotonin (5-HT) on the same preparation. Expand
Anti-inflammatory activity of the hexane extract of Byrsonima crassifolia seeds in experimental animal models.
The results indicate that the anti-inflammatory effect of NS on mouse paw edema occurs via the inhibition of NO production, as does theAnti- inflammatory effect of L-NAME but not the anti -inflammatory effectof diclofenac. Expand
Screening of the topical anti-inflammatory activity of the bark of Acacia cornigera Willdenow, Byrsonima crassifolia Kunth, Sweetia panamensis Yakovlev and the leaves of Sphagneticola trilobata Hitchcock.
Lipophilic extracts from these species can be regarded as potential sources of anti-inflammatory principles and reduced the Croton oil-induced ear dermatitis in mice. Expand
Anti-inflammatory effect of birsonimadiol from seeds of Byrsonima crassifolia
BIR suppressed production of nitric oxide and prostaglandin E2, decreased gene expression of cyclooxygenase-2, inhibited tumor necrosis factor (TNF)-α, and protein secretion of interleukin IL-6, and was an effective topical anti-inflammatory agent in experimental models of acute and chronic dermatitis. Expand
Anti-inflammatory effect of birsonimadiol from seeds of Byrsonima crassifolia
The new compound identified as 16α,23α-dihydroxy-3β,28β,30α-triacetoxy-olean-12-ene, named birsonimadiol (BIR) was isolated from Byrsonima crassifolia seeds using activity-guided fractionation andExpand
Inhibitory Activities of Guaianolides from the Seeds of Byrsonima Crassifolia against Protein Glycation In Vitro
In-depth chromatographicinvestigation on the hexane extract of Byrsonima crassifolia led to the identification of eight new guaianolides. Structural elucidation was established on the basis ofExpand
As a part of a project directed toward the discovery of oral antimicrobial compounds from plants, eight known compounds, β-amyrin (1), betulin (2), betulinic acid (3), oleanolic acid (4), quercetinExpand
Hypoglycemic Effects of sesquiterpene lactones from Byrsonima crassifolia
Byrsonina types improved this glucose metabolism by reducing insulin resistance and by stimulating insulin production due to protection effect for pancreatic β-cells against oxidative stress, lipid abnormalities were reduced and, chronic inflammation responses were alleviated producing a hepatoprotective role. Expand
Four methods of extraction in leaves of Byrsonima crassifolia and their effects in gastrointestinal smooth muscle strips
Byrsonima crassifolia leaves were extracted via maceration (BrMa), percolation (BrPer), soxhlet (BrSox) and sonication (BrSon). Spectrophotometric estimation of chlorophylls and analysis ofExpand


Plants used in Guatemala for the treatment of dermatophytic infections. 1. Screening for antimycotic activity of 44 plant extracts.
Fungicidal and fungistatic activities as well as the minimal inhibitory concentration were demonstrated and provide a scientific basis for the use of these plants for the treatment of dermatophyte infections in man. Expand
Plants used in Guatemala for the treatment of gastrointestinal disorders. 1. Screening of 84 plants against enterobacteria.
The results indicate a scientific basis for use of these medicinal plants for attacking enterobacterial infections in man. Expand
Preliminary chemical characterization of pharmacologically active compounds in aqueous plant extracts.
A test system is described which, based on the use of ion exchangers, gel filtration on Sephadex, and extraction with organic solvents, gives information about the stability, molecular size, charge,Expand
Volatile composition of certain Amazonian fruits
Abstract The volatile constituents of several Amazonian fruits—bacuri, cupuacu, maruci and tapereba—were isolated by steam distillation-extraction of pulp or juice from the canned fruits. EssencesExpand
Contractile serotonergic receptor in rat stomach fundus.
Neither the potency nor maximum response of these agonists in contracting the rat stomach fundus correlated with the affinity of agonists at 5HT1A, 5Ht1B or5HT1C binding sites, suggesting that these agents have little, if any, affinity for the serotonergic receptor-mediating contraction in the fundus. Expand
  • J. Vane
  • Chemistry, Medicine
  • British journal of pharmacology and chemotherapy
  • 1957
The movements of a strip of fundus from a rat stomach, suspended in a 5 ml. bath at 37°, are recorded by a spring‐loaded lever. The muscle is stretched for 15 to 30 sec. between contractions. 1 ng.Expand
Manual of Pharmacologic Calculations: With Computer Programs
Manual of Pharmacologic Calculations with Computer Programs. By R. J. Tallarida and R. B. Murray. New York, Heidelberg and Berlin, Springer‐Verlag, 1981. ix, 150 p. 24·5 cm. Unpriced.