Pharmacological and chemical screening of Byrsonima crassifolia, a medicinal tree from Mexico. Part I.

@article{Bjar1993PharmacologicalAC,
  title={Pharmacological and chemical screening of Byrsonima crassifolia, a medicinal tree from Mexico. Part I.},
  author={Ezra B{\'e}jar and Marvin H. Malone},
  journal={Journal of ethnopharmacology},
  year={1993},
  volume={39 2},
  pages={
          141-58
        }
}
Leaf and bark extracts of Byrsonima crassifolia displayed concentration-dependent, spasmogenic effects on rat fundus in vitro and biphasic effects on rat jejunum and ileum in vitro. Dose-related in vivo effects in intact rats using hippocratic screening were: decrease in motor activity, mild analgesia, back tonus, enophthalmos, reversible palpebral ptosis, ear blanching, Robichaud positive, catalepsy (awake) and strong hypothermia. Rat fundus in vitro was used as the bioassay to carry out an… Expand
Antidepressant effect and pharmacological evaluation of standardized extract of flavonoids from Byrsonima crassifolia.
TLDR
The present results showed that the methanolic extract standardized on flavonoids content of Byrsonima crassifolia possesses potential antidepressant-like effects in the FST in mice, and could be considered as relatively safe toxicologically with no deaths of mice when orally administered at 2000 mg/kg. Expand
Constituents of Byrsonima Crassifolia and Their Spasmogenic Activity
TLDR
Biological evaluations showed that five compounds (betulin, betulinic acid, hyperin, quercetin, and ursenaldehyde) exhibited spasmogenic activity on isolated rat fundus, and three isolates showed noncompetitive antagonism to serotonin (5-HT) on the same preparation. Expand
Anti-inflammatory activity of the hexane extract of Byrsonima crassifolia seeds in experimental animal models.
TLDR
The results indicate that the anti-inflammatory effect of NS on mouse paw edema occurs via the inhibition of NO production, as does theAnti- inflammatory effect of L-NAME but not the anti -inflammatory effectof diclofenac. Expand
Screening of the topical anti-inflammatory activity of the bark of Acacia cornigera Willdenow, Byrsonima crassifolia Kunth, Sweetia panamensis Yakovlev and the leaves of Sphagneticola trilobata Hitchcock.
TLDR
Lipophilic extracts from these species can be regarded as potential sources of anti-inflammatory principles and reduced the Croton oil-induced ear dermatitis in mice. Expand
Anti-inflammatory effect of birsonimadiol from seeds of Byrsonima crassifolia
TLDR
BIR suppressed production of nitric oxide and prostaglandin E2, decreased gene expression of cyclooxygenase-2, inhibited tumor necrosis factor (TNF)-α, and protein secretion of interleukin IL-6, and was an effective topical anti-inflammatory agent in experimental models of acute and chronic dermatitis. Expand
Anti-inflammatory effect of birsonimadiol from seeds of Byrsonima crassifolia
The new compound identified as 16α,23α-dihydroxy-3β,28β,30α-triacetoxy-olean-12-ene, named birsonimadiol (BIR) was isolated from Byrsonima crassifolia seeds using activity-guided fractionation andExpand
Inhibitory Activities of Guaianolides from the Seeds of Byrsonima Crassifolia against Protein Glycation In Vitro
In-depth chromatographicinvestigation on the hexane extract of Byrsonima crassifolia led to the identification of eight new guaianolides. Structural elucidation was established on the basis ofExpand
ANTIBACTERIAL COMPOUNDS ISOLATED FROM BYRSONIMA CRASSIFOLIA
As a part of a project directed toward the discovery of oral antimicrobial compounds from plants, eight known compounds, β-amyrin (1), betulin (2), betulinic acid (3), oleanolic acid (4), quercetinExpand
Hypoglycemic Effects of sesquiterpene lactones from Byrsonima crassifolia
TLDR
Byrsonina types improved this glucose metabolism by reducing insulin resistance and by stimulating insulin production due to protection effect for pancreatic β-cells against oxidative stress, lipid abnormalities were reduced and, chronic inflammation responses were alleviated producing a hepatoprotective role. Expand
Four methods of extraction in leaves of Byrsonima crassifolia and their effects in gastrointestinal smooth muscle strips
Byrsonima crassifolia leaves were extracted via maceration (BrMa), percolation (BrPer), soxhlet (BrSox) and sonication (BrSon). Spectrophotometric estimation of chlorophylls and analysis ofExpand
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