Pharmacological and Therapeutic Properties of Valproate

  title={Pharmacological and Therapeutic Properties of Valproate},
  author={E. Perucca},
  journal={CNS Drugs},
  • E. Perucca
  • Published 2002
  • Medicine
  • CNS Drugs
  • Thirty-five years since its introduction into clinical use, valproate (valproic acid) has become the most widely prescribed antiepileptic drug (AED) worldwide. Its pharmacological effects involve a variety of mechanisms, including increased γ-aminobutyric acid (GABA)-ergic transmission, reduced release and/or effects of excitatory amino acids, blockade of voltage-gated sodium channels and modulation of dopaminergic and serotoninergic transmission.Valproate is available in different dosage forms… CONTINUE READING
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