Pharmacological and Therapeutic Properties of Valproate

@article{Perucca2002PharmacologicalAT,
  title={Pharmacological and Therapeutic Properties of Valproate},
  author={E. Perucca},
  journal={CNS Drugs},
  year={2002},
  volume={16},
  pages={695-714}
}
  • E. Perucca
  • Published 2002
  • Medicine
  • CNS Drugs
  • Thirty-five years since its introduction into clinical use, valproate (valproic acid) has become the most widely prescribed antiepileptic drug (AED) worldwide. Its pharmacological effects involve a variety of mechanisms, including increased γ-aminobutyric acid (GABA)-ergic transmission, reduced release and/or effects of excitatory amino acids, blockade of voltage-gated sodium channels and modulation of dopaminergic and serotoninergic transmission.Valproate is available in different dosage forms… CONTINUE READING
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    • 97
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    • 253
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    • 66
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    • 59
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    References

    SHOWING 1-10 OF 156 REFERENCES
    Clinical Pharmacokinetics of Valproic Acid — 1988
    • 166
    Valproate: a reappraisal of its pharmacodynamic properties and mechanisms of action
    • W. Löscher
    • Medicine, Biology
    • Progress in Neurobiology
    • 1999
    • 477
    Clinical Pharmacokinetics of Valproic Acid
    • 321
    Disposition of sodium valproate in epileptic patients.
    • 110