Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice.

@article{AlMassadi2016PharmacologicalAG,
  title={Pharmacological and Genetic Manipulation of p53 in Brown Fat at Adult But Not Embryonic Stages Regulates Thermogenesis and Body Weight in Male Mice.},
  author={Omar Al-Massadi and Bego{\~n}a Porteiro and Doreen Kuhlow and Markus K{\"o}hler and Maria J. Gonzalez-Rellan and Montserrat Garc{\'i}a-Lavandeira and Esther D{\'i}az-Rodr{\'i}guez and Maximiliano Qui{\~n}ones and A. Alija Senra and Clara Villalba Alvarez and Miguel L{\'o}pez and Carlos Enrique Atoche Di{\'e}guez and Tim J Schulz and Rub{\'e}n Nogueiras},
  journal={Endocrinology},
  year={2016},
  volume={157 7},
  pages={
          2735-49
        }
}
p53 is a well-known tumor suppressor that plays multiple biological roles, including the capacity to modulate metabolism at different levels. However, its metabolic role in brown adipose tissue (BAT) remains largely unknown. Herein we sought to investigate the physiological role of endogenous p53 in BAT and its implication on BAT thermogenic activity and energy balance. To this end, we generated and characterized global p53-null mice and mice lacking p53 specifically in BAT. Additionally we… CONTINUE READING
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